Clinical Trial Validates Oleosome-growth Factors Outperform Retinol for Visible Skin Results

Consumers’ relentless pursuit of youthful skin continues to drive innovation in skincare science. For decades, retinol has dominated the anti-aging category - delivering visible improvements, but often at the cost of irritation and sensitivity [1]. That narrative is shifting.

After four years of research, Core Biogenesis has developed the next-generation alternative: Oleosome-Growth Factors, powered by biomimetic active ingredients Oleosome-EGF and Oleosome-FGF-2. The company’s proprietary whole-plant biofactory technology  produces growth factors fused to plant-seed oleosomes which enables 8-10X greater stability, deeper dermal delivery, and accelerated visible results.

Oleosome Growth Factor Serum, a formulation containing 1.0% Oleosome-EGF and 1.0% Oleosome-FGF-2,  demonstrated statistically significant results across four skin aging markers against 0.3% retinol in a 60-day head-to-head clinical trial [2].   The Oleosome Growth Factor Serum decreased wrinkle depth, wrinkle length, improved skin smoothness, and boosted skin brightness with a statistically significant superior outcome than retinol across four skin aging markers. 

Core Biogenesis positions  Oleosome-Growth Factors as the new benchmark in anti-aging skincare: biomimetic, clinically proven, ethically sourced, and built for the future of beauty.

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