H. J. Park, B. G. Song
Hair loss is a multifactorial condition in which androgen signaling plays a central role. Cosmetic and pharmaceutical approaches have focused on reducing androgen levels or inhibiting 5á-reductase activity; however, these strategies are associated with limited efficacy or concerns regarding long-term use. Recent advances in trichology indicate that androgen receptor (AR) nuclear translocation represents a critical regulatory step in androgen-driven hair follicle miniaturization. In this study, Tricora™ Melo A, a novel ingredient derived from upcycled Korean melon (Cucumis melo var. makuwa) leaves, was evaluated for its ability to modulate androgen receptor signaling. Melon leaves, typically discarded during processing, were repurposed through an upcycling process to obtain a flavonoid-rich extract containing Meloside A as bioactive component.
In vitro evaluation using AR-responsive cell models demonstrated that Tricora™ Melo A reduced androgen receptor translocation to the nucleus in the presence of dihydrotestosterone, without affecting cell viability. In addition, moderate downregulation of androgen receptor expression was observed, suggesting a complementary regulatory effect on androgen signaling. This mode of action differs from conventional androgen-blocking strategies by modulating receptor behavior rather than suppressing hormone production.
These results suggest that Tricora™ Melo A is a sustainable, plant-derived cosmetic ingredient offering a differentiated, non-hormonal approach to hair loss care.
