The architecture of baby skin is defined by an open, flexible and highly organized dermal matrix dominated by collagen III. This collagen, essential for the skin’s softness, cushioned feel and natural luminosity during early life, progressively declines with age. As its levels diminish, the dermis loses its multidirectional structure and becomes increasingly rigid and linear, marking the onset of reduced bounce, smoothness and uniformity. In response to this fundamental biological shift, LipoTrue introduces CO///A3™, a biomimetic fragment of collagen III designed to restore the key functions associated with youthful skin and reactivate the baby‑like skin code.
CO///A3™ is produced through the Wild Plants as Biofactories platform, where wild plants serve as transient expression systems for human protein fragments. Cultivated under vertical farming conditions, this technology ensures a controlled, sustainable and non‑GMO process that yields high‑purity, endotoxin‑free, vegan‑certified molecules with proper post‑translational modifications. In the case of CO///A3™, this approach enables the production of a functional collagen III fragment capable of reactivating dermal processes that naturally deteriorate with age.
The mechanism of action of CO///A3™ is built on three coordinated pillars that reconstruct the structural and functional essence of baby‑like skin.
The first pillar, Rebuild & organize the dermal matrix, focuses on restoring the flexible mesh that defines dermal strength and elasticity. Collagen III naturally guides fibrillogenesis, ensuring that collagen I assembles into well‑spaced, supple fibrils rather than rigid bundles. CO///A3™ supports this process by boosting key extracellular matrix components – collagens I and III, elastin and LOX – helping reopen the dermal architecture and enabling elastic fibers to stretch and recoil smoothly. This reorganization recreates the structural conditions necessary for youthful resilience and comfort.
The second pillar, Restore the baby‑skin identity, targets the way fibroblasts sense and interpret their environment. Integrins act as mechanosensors that translate matrix structure into cellular behavior. With age, integrin patterns shift toward those associated with stiffness and reduced regenerative capacity. CO///A3™ helps revert this shift by promoting a younger integrin profile, restoring a softer, more compliant matrix environment and reestablishing the cellular identity characteristic of youthful skin.
The third pillar, Reprogram skin dynamics, enhances the coordination and renewal capacity of the tissue. CO///A3™ increases lumican, a key regulator of collagen fibril diameter and ECM harmony, and boosts TSP4, a matricellular protein that organizes collagen I and III and supports fibroblast adhesion and migration. These actions refine the collagen network and promote a more active, responsive and well‑orchestrated dermal environment.
Through this triple mechanism, CO///A3™ reactivates the baby‑like skin code, restoring the softness, bounce and natural glow that define youthful skin. By addressing the biological origin of dermal aging and rebuilding the structural logic of early‑life skin, CO///A3™ represents a new generation of biomimetic actives capable of transforming the skin’s architecture from within.
LipoTrue S.L – Headquarters
C/ Imaginació 15,
Pol. Ind. Les Marines, 08850
Gavá (Barcelona), Spain
Tel: (+34) 935 477 609
Fax: (+34) 931 932 060
www.lipotrue.com
info@lipotrue.com
